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Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance

Received: 18 May 2023     Accepted: 6 June 2023     Published: 8 July 2023
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Abstract

Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future.

Published in American Journal of Applied Scientific Research (Volume 9, Issue 3)
DOI 10.11648/j.ajasr.20230903.11
Page(s) 82-89
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Ankylosing Spondylitis, Monocyte Subtype, Cytokines, Flow Cytometry

References
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Cite This Article
  • APA Style

    Miao Yu, Xiuli Tan. (2023). Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. American Journal of Applied Scientific Research, 9(3), 82-89. https://doi.org/10.11648/j.ajasr.20230903.11

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    ACS Style

    Miao Yu; Xiuli Tan. Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. Am. J. Appl. Sci. Res. 2023, 9(3), 82-89. doi: 10.11648/j.ajasr.20230903.11

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    AMA Style

    Miao Yu, Xiuli Tan. Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. Am J Appl Sci Res. 2023;9(3):82-89. doi: 10.11648/j.ajasr.20230903.11

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  • @article{10.11648/j.ajasr.20230903.11,
      author = {Miao Yu and Xiuli Tan},
      title = {Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance},
      journal = {American Journal of Applied Scientific Research},
      volume = {9},
      number = {3},
      pages = {82-89},
      doi = {10.11648/j.ajasr.20230903.11},
      url = {https://doi.org/10.11648/j.ajasr.20230903.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajasr.20230903.11},
      abstract = {Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance
    AU  - Miao Yu
    AU  - Xiuli Tan
    Y1  - 2023/07/08
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ajasr.20230903.11
    DO  - 10.11648/j.ajasr.20230903.11
    T2  - American Journal of Applied Scientific Research
    JF  - American Journal of Applied Scientific Research
    JO  - American Journal of Applied Scientific Research
    SP  - 82
    EP  - 89
    PB  - Science Publishing Group
    SN  - 2471-9730
    UR  - https://doi.org/10.11648/j.ajasr.20230903.11
    AB  - Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future.
    VL  - 9
    IS  - 3
    ER  - 

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Author Information
  • Jilin Medical Device Inspection and Research Institute, Changchun, China

  • Jilin Medical Device Inspection and Research Institute, Changchun, China

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